Drugs contraindicated in lactation pdf Topi Topi

drugs contraindicated in lactation pdf

Drugs and the Breastfeeding Mother A New Clinical Report LactMed-Drugs and Lactation Database (LactMed) - A peer-reviewed and fully referenced database of drugs to which breastfeeding mothers may be exposed. Among the data included are maternal and infant levels of drugs, possible effects on breastfed infants and on lactation, and alternate drugs …

Contraindications to breastfeeding 06

Drugs in breastfeeding APILAM. Regardless of pharmacological characteristics, drugs that are known to be toxic to infants, such as antineoplastic drugs, radioactive drugs or drugs of abuse, are contraindicated during the breastfeeding period., CONTRAINDICATIONS TO BREASTFEEDING Infants with galactosaemia should not receive breast milk HIV in UK • Always check maternal HIV status before breastfeeding • Breastfeeding absolutely contraindicated (in UK) • If you are concerned that mother intends to breastfeed, ensure an HIV specialist explains the risk to which infant will be exposed HIV in developing countries • If returning to.

breastfeeding drugs in pregnancy lactation is the worlds leading authority on the safe use of drugs in pregnant and lactating women it drives decision making by providing expert analysis and essential. drugs in pregnancy and lactation Education WorldBook Center WorldBook ID bc32cb Education WorldBook Center evidence based information listing nearly 1200 commonly prescribed drugs taken … n--NEW list of drugs contraindicated in pregnancy n --NEW list of drugs known to cause human developmental toxicity n --NEW More summaries at the beginning for pregnancy and breastfeeding

DRUG INTERACTIONS-----­ Avoid coadministration with drugs that are substrates of organic cation KRINTAFEL is contraindicated in breastfeeding women when the infant is found to be G6PD deficient or the G6PD status of the infant is unknown [see Contraindications (4)]. Advise the woman with a G6PD-deficient infant or if the G6PD status of the infant is unknown not to breastfeed for 3 months Many mothers need to take medications during breastfeeding. Although many drugs are safe to use when you're breastfeeding, most will get into your milk to …

Drugs in Pregnacy and Lactation, 6th edition: Gerald G Briggs BPharm, Roger K Freeman MD, Sumner J Yaffe MD By Lippincott Williams & Wilkins Publishers Drugs in Pregnacy and Lactation, 6th edition: Gerald G Briggs BPharm, Roger K Freeman MD, Sumner J Yaffe MD By Lippincott Williams & Wilkins Publishers

Most drugs are compatible with breastfeeding, but depend on the agent and timing. LactMed is a drug database with breastfeeding safety information According to the American Academy of Pediatrics and the Canadian Pediatric Society, the following are considered definitive contraindications to breastfeeding : Drug which has been studied in a limited number of breastfeeding women without an increase in adverse effects in the infant; and/or, the evidence of a demonstrated risk which is likely to follow use of this medication in a breastfeeding woman is remote.

Drugs in this class may be used in pregnancy if the benefits to the mother outweigh the risk to the fetus (i.e. a life threatening situation or a serious disease for which safer medication cannot be … The prescribing information (drug label) and LactMed (a drugs and lactation database, also available in a mobile app) will have the information to help a provider decide whether to use a drug in a

Therefore, co-administration of domperidone with certain drugs is contraindicated (see . section . 4.3 Contraindications). Caution should be exercised when domperidone is coadministered with pote- nt CYP3A4 inhibitors which have not been shown to cause QT interval prolongation or drugs which have been shown to cause QT interval prolongation (see 4.4 Special warnings and section . precautions 3 SULFONAMIDES • Contraindications: – Hypersensitivity to the drugs – Pregnancy/lactation – Children under the age of 2 – Infections caused by group A beta-hemolytic

breastfeeding in most instances in which drug therapy is indicated. Two drugs are worthy of mention because they are commonly prescribed in puerperal women but their potential transmission in breast milk and their effects on a neonate remain controversial. More information is available from obstetric drug information services in your State or Territory. The database does not include all therapeutic goods, because certain types of therapeutic good are usually exempt from pregnancy categorisation .

Drugs Contraindicated In Breast Feeding Mnemonic: BREAST B romocryptin / B enzodiazepines R adioactive isotopes / R izatriptan 3 SULFONAMIDES • Contraindications: – Hypersensitivity to the drugs – Pregnancy/lactation – Children under the age of 2 – Infections caused by group A beta-hemolytic

Therefore, co-administration of domperidone with certain drugs is contraindicated (see . section . 4.3 Contraindications). Caution should be exercised when domperidone is coadministered with pote- nt CYP3A4 inhibitors which have not been shown to cause QT interval prolongation or drugs which have been shown to cause QT interval prolongation (see 4.4 Special warnings and section . precautions CONTRAINDICATIONS -----­ EPIVIR is contraindicated in patients with previous hypersensitivity reaction DRUG INTERACTIONS-----Sorbitol: Coadministration of lamivudine and sorbitol may decrease lamivudine concentrations; when possible, avoid chronic coadministration. (7.2) USE IN SPECIFIC POPULATIONS -----­ • Lactation: Women infected with HIV should be instructed not to …

Contraindications to Breastfeeding or Feeding Expressed Breast Milk to Infants. Physicians should make case-by-case assessments to determine whether a woman’s environmental exposure, her own medical condition, or the medical condition of the infant warrants her to interrupt, stop, or never start breastfeeding. 3 SULFONAMIDES • Contraindications: – Hypersensitivity to the drugs – Pregnancy/lactation – Children under the age of 2 – Infections caused by group A beta-hemolytic

3 Objectives (continued) •Discuss issues faced by women for whom breastfeeding is contraindicated or not advisable, including stigma •Review appropriately tailored, individualized These images are a random sampling from a Bing search on the term "Medications in Lactation." Click on the image (or right click) to open the source website in a new browser window. Click on the image (or right click) to open the source website in a new browser window.

Social Drugs and Breastfeeding Health e-Learning

drugs contraindicated in lactation pdf

Drugs in Lactation Breastfeeding Analgesic scribd.com. Regardless of pharmacological characteristics, drugs that are known to be toxic to infants, such as antineoplastic drugs, radioactive drugs or drugs of abuse, are contraindicated during the breastfeeding period., I. FACTS ABOUT DRUGS IN LACTATION 1. Most drugs pass through breastmilk. 2. 1% less of maternal dose appear in breastmilk. 3. Few drugs are contraindicated. 4. Some drugs cause side effects on the baby. 5. Baby’s exposure to a drug can be minimized..

Drugs Used in Lactating MothersauthorSTREAM. DRUG INTERACTIONS-----­ Avoid coadministration with drugs that are substrates of organic cation KRINTAFEL is contraindicated in breastfeeding women when the infant is found to be G6PD deficient or the G6PD status of the infant is unknown [see Contraindications (4)]. Advise the woman with a G6PD-deficient infant or if the G6PD status of the infant is unknown not to breastfeed for 3 months, Even though most drugs and therapeutics are safe for breastfeeding mothers and infants, the AAP advises all physicians to obtain the most up-to-date information on drugs and lactation. Antibiotics are one of the most common medications mothers are prescribed and all pass in some degree into milk..

DRUGS IN LACTATION St. James's Hospital - Internet

drugs contraindicated in lactation pdf

Breastfeeding and Medication AAP.org. These images are a random sampling from a Bing search on the term "Medications in Lactation." Click on the image (or right click) to open the source website in a new browser window. Click on the image (or right click) to open the source website in a new browser window. all drugs may be contraindicated while breastfeeding, there remains little data on this topic. Methotrexate (MTX) is the first line of treatment for rheumatoid arthritis (RA), which has a high incidence in women of childbearing age. Disease activity of RA often decreases during pregnancy but tends to flare following delivery, necessitating the reestablishment of treatment. Only one case report.

drugs contraindicated in lactation pdf


For drugs with greater inherent toxicity such as cytotoxic agents, ergotamine, gold salts, immunosuppressives and isotretinoin, the cut-off of 10% is too high and breastfeeding is contraindicated. As a general rule, maternal use of topical preparations such as creams, nasal sprays or inhalers would be expected to carry less risk to a breastfed infant than systemically administered drugs. LactMed-Drugs and Lactation Database (LactMed) - A peer-reviewed and fully referenced database of drugs to which breastfeeding mothers may be exposed. Among the data included are maternal and infant levels of drugs, possible effects on breastfed infants and on lactation, and alternate drugs …

Download [pdf 610kb] Overview This document has been developed to help the health worker decide whether a mother who is breastfeeding and who needs treatment with drugs can take the necessary medication and still continue breastfeeding safely. 3 Objectives (continued) •Discuss issues faced by women for whom breastfeeding is contraindicated or not advisable, including stigma •Review appropriately tailored, individualized

n--NEW list of drugs contraindicated in pregnancy n --NEW list of drugs known to cause human developmental toxicity n --NEW More summaries at the beginning for pregnancy and breastfeeding LactMed-Drugs and Lactation Database (LactMed) - A peer-reviewed and fully referenced database of drugs to which breastfeeding mothers may be exposed. Among the data included are maternal and infant levels of drugs, possible effects on breastfed infants and on lactation, and alternate drugs …

Drugs in this class may be used in pregnancy if the benefits to the mother outweigh the risk to the fetus (i.e. a life threatening situation or a serious disease for which safer medication cannot be … recommendatio"n that it is "usually compatible with breastfeeding~ • However: Domperidone is only 13-17% bioavailable orally due to significantfirst-pass hepatic and intestinal metabolism .

Contraindications (4),and Drug Interactions (7.2)]: Loss of therapeutic effect of DELSTRIGO and possible development of resistance. Possible clinically significant adverse reactions from greater exposures of a component of Iodine has been deleted from the Summary and the Table as it is not contraindicated during breastfeeding.

Most drugs are compatible with breastfeeding, but depend on the agent and timing. LactMed is a drug database with breastfeeding safety information According to the American Academy of Pediatrics and the Canadian Pediatric Society, the following are considered definitive contraindications to breastfeeding : I. FACTS ABOUT DRUGS IN LACTATION 1. Most drugs pass through breastmilk. 2. 1% less of maternal dose appear in breastmilk. 3. Few drugs are contraindicated. 4. Some drugs cause side effects on the baby. 5. Baby’s exposure to a drug can be minimized.

Drugs in Pregnacy and Lactation, 6th edition: Gerald G Briggs BPharm, Roger K Freeman MD, Sumner J Yaffe MD By Lippincott Williams & Wilkins Publishers Few medications are contraindicated while breastfeeding. Is it safe for mothers to use prescription medications while breastfeeding? Usually. A 2013 clinical report by the American Academy of Pediatrics (AAP), “The Transfer of Drugs and Therapeutics into Human Breast Milk: An Update on Selected Topics,” indicates that most medications and immunizations are safe to use during lactation

These images are a random sampling from a Bing search on the term "Medications in Lactation." Click on the image (or right click) to open the source website in a new browser window. Click on the image (or right click) to open the source website in a new browser window. Drugs contraindicated during breastfeeding include anticancer drugs, lithium, oral retinoids, iodine, amiodarone and gold salts. An understanding of the principles underlying the transfer into breast milk is important, as is an

3 SULFONAMIDES • Contraindications: – Hypersensitivity to the drugs – Pregnancy/lactation – Children under the age of 2 – Infections caused by group A beta-hemolytic Drugs contraindicated during breastfeeding include anticancer drugs, lithium, oral retinoids, iodine, amiodarone and gold salts. An understanding of the principles underlying the transfer into breast milk is important, as is an

Drugs Contraindicated In Breast Feeding Mnemonic: BREAST B romocryptin / B enzodiazepines R adioactive isotopes / R izatriptan AMERICAN ACADEMY OF PEDIATRICS Committee on Drugs The Transfer of Drugs and Other Chemicals Into Human Milk ABSTRACT. The American Academy of Pediatrics places emphasis on increasing breastfeeding in the United States. A common reason for the cessation of breastfeeding is the use of medication by the nursing mother and advice by her physician to stop nursing. Such …

drugs contraindicated in lactation pdf

Social Drugs and Breastfeeding: Handling an issue that isn’t black and white Denise Fisher Use of social drugs by a minority of pregnant and breastfeeding mothers is a fact of life. CONTRAINDICATIONS TO BREASTFEEDING Infants with galactosaemia should not receive breast milk HIV in UK • Always check maternal HIV status before breastfeeding • Breastfeeding absolutely contraindicated (in UK) • If you are concerned that mother intends to breastfeed, ensure an HIV specialist explains the risk to which infant will be exposed HIV in developing countries • If returning to

DRUGS IN LACTATION St. James's Hospital - Internet

drugs contraindicated in lactation pdf

WHO Breastfeeding and maternal medication. Breastfeeding may not be in the best interest of the baby in the following conditions: • The baby has galactosaemia, • Mother has active untreated tuberculosis, T-cell, CONTRAINDICATIONS -----­ EPIVIR is contraindicated in patients with previous hypersensitivity reaction DRUG INTERACTIONS-----Sorbitol: Coadministration of lamivudine and sorbitol may decrease lamivudine concentrations; when possible, avoid chronic coadministration. (7.2) USE IN SPECIFIC POPULATIONS -----­ • Lactation: Women infected with HIV should be instructed not to ….

Drugs to Avoid in Breastfeeding Women Brinsmead

PNSG 2303 Pharmacology II Anti-Infectives Chapters 6 7 8. Contraindications to Breastfeeding or Feeding Expressed Breast Milk to Infants. Physicians should make case-by-case assessments to determine whether a woman’s environmental exposure, her own medical condition, or the medical condition of the infant warrants her to interrupt, stop, or never start breastfeeding., Contraindicated drugs during lactation Drugs that require temporary withdrawal of breast feeding Effects on breast feeding infants METRONIDAZOLE If a single dose of the drug has been given, then the infant should not be nursed for 1 day. This allows drug get excreted in milk. The drug is found to produce diarrhea and lactose intolerance. It als o has mutagenic and carcinogenic properties..

Drugs in Pregnacy and Lactation, 6th edition: Gerald G Briggs BPharm, Roger K Freeman MD, Sumner J Yaffe MD By Lippincott Williams & Wilkins Publishers Few medications are contraindicated while breastfeeding. Is it safe for mothers to use prescription medications while breastfeeding? Usually. A 2013 clinical report by the American Academy of Pediatrics (AAP), “The Transfer of Drugs and Therapeutics into Human Breast Milk: An Update on Selected Topics,” indicates that most medications and immunizations are safe to use during lactation

Many mothers need to take medications during breastfeeding. Although many drugs are safe to use when you're breastfeeding, most will get into your milk to … Contraindicated drugs during lactation Drugs that require temporary withdrawal of breast feeding Effects on breast feeding infants METRONIDAZOLE If a single dose of the drug has been given, then the infant should not be nursed for 1 day. This allows drug get excreted in milk. The drug is found to produce diarrhea and lactose intolerance. It als o has mutagenic and carcinogenic properties.

3 SULFONAMIDES • Contraindications: – Hypersensitivity to the drugs – Pregnancy/lactation – Children under the age of 2 – Infections caused by group A beta-hemolytic 3 Objectives (continued) •Discuss issues faced by women for whom breastfeeding is contraindicated or not advisable, including stigma •Review appropriately tailored, individualized

recommendatio"n that it is "usually compatible with breastfeeding~ • However: Domperidone is only 13-17% bioavailable orally due to significantfirst-pass hepatic and intestinal metabolism . 3 Objectives (continued) •Discuss issues faced by women for whom breastfeeding is contraindicated or not advisable, including stigma •Review appropriately tailored, individualized

Many mothers need to take medications during breastfeeding. Although many drugs are safe to use when you're breastfeeding, most will get into your milk to … breastfeeding drugs in pregnancy lactation is the worlds leading authority on the safe use of drugs in pregnant and lactating women it drives decision making by providing expert analysis and essential. drugs in pregnancy and lactation Education WorldBook Center WorldBook ID bc32cb Education WorldBook Center evidence based information listing nearly 1200 commonly prescribed drugs taken …

Few medications are contraindicated while breastfeeding. Is it safe for mothers to use prescription medications while breastfeeding? Usually. A 2013 clinical report by the American Academy of Pediatrics (AAP), “The Transfer of Drugs and Therapeutics into Human Breast Milk: An Update on Selected Topics,” indicates that most medications and immunizations are safe to use during lactation Therefore, co-administration of domperidone with certain drugs is contraindicated (see . section . 4.3 Contraindications). Caution should be exercised when domperidone is coadministered with pote- nt CYP3A4 inhibitors which have not been shown to cause QT interval prolongation or drugs which have been shown to cause QT interval prolongation (see 4.4 Special warnings and section . precautions

INFORMATION XOFLUZA is contraindicated in patients with a history of hypersensitivity to These highlights do not include all the information needed to use XOFLUZA safely and effectively. See full prescribing information for XOFLUZA. XOFLUZATM (baloxavir marboxil) tablets, for oral use Initial U.S. Approval: 2018 -----INDICATIONS AND USAGE----- XOFLUZATM is a polymerase acidic (PA) … Iodine has been deleted from the Summary and the Table as it is not contraindicated during breastfeeding.

Drugs in Pregnacy and Lactation, 6th edition: Gerald G Briggs BPharm, Roger K Freeman MD, Sumner J Yaffe MD By Lippincott Williams & Wilkins Publishers Most drugs are compatible with breastfeeding, but depend on the agent and timing. LactMed is a drug database with breastfeeding safety information According to the American Academy of Pediatrics and the Canadian Pediatric Society, the following are considered definitive contraindications to breastfeeding :

Even though most drugs and therapeutics are safe for breastfeeding mothers and infants, the AAP advises all physicians to obtain the most up-to-date information on drugs and lactation. Antibiotics are one of the most common medications mothers are prescribed and all pass in some degree into milk. Iodine has been deleted from the Summary and the Table as it is not contraindicated during breastfeeding.

For drugs with greater inherent toxicity such as cytotoxic agents, ergotamine, gold salts, immunosuppressives and isotretinoin, the cut-off of 10% is too high and breastfeeding is contraindicated. As a general rule, maternal use of topical preparations such as creams, nasal sprays or inhalers would be expected to carry less risk to a breastfed infant than systemically administered drugs. The use of medications by the nursing mother is a common reason for interrupting breastfeeding. Few drugs have been demonstrated to be absolutely contraindicated during breastfeeding.

Mnemonic for contraindicated drugs in breast feeding. Few medications are contraindicated while breastfeeding. Is it safe for mothers to use prescription medications while breastfeeding? Usually. A 2013 clinical report by the American Academy of Pediatrics (AAP), “The Transfer of Drugs and Therapeutics into Human Breast Milk: An Update on Selected Topics,” indicates that most medications and immunizations are safe to use during lactation, Social Drugs and Breastfeeding: Handling an issue that isn’t black and white Denise Fisher Use of social drugs by a minority of pregnant and breastfeeding mothers is a fact of life..

Transfer of drugs and other chemicals into human milk

drugs contraindicated in lactation pdf

Social Drugs and Breastfeeding Health e-Learning. Contraindications to Breastfeeding or Feeding Expressed Breast Milk to Infants. Physicians should make case-by-case assessments to determine whether a woman’s environmental exposure, her own medical condition, or the medical condition of the infant warrants her to interrupt, stop, or never start breastfeeding., CONTRAINDICATIONS TO BREASTFEEDING Infants with galactosaemia should not receive breast milk HIV in UK • Always check maternal HIV status before breastfeeding • Breastfeeding absolutely contraindicated (in UK) • If you are concerned that mother intends to breastfeed, ensure an HIV specialist explains the risk to which infant will be exposed HIV in developing countries • If returning to.

Drugs and devices for increasing milk supply GTP

drugs contraindicated in lactation pdf

Contraindications to Breastfeeding or Feeding Expressed. Contraindicated during lactation. Some drugs contraindicated during lactation are mentioned below. If any of these drugs are considered crucial for the mother’s health, breast-feeding should be Iodine has been deleted from the Summary and the Table as it is not contraindicated during breastfeeding..

drugs contraindicated in lactation pdf


Many mothers need to take medications during breastfeeding. Although many drugs are safe to use when you're breastfeeding, most will get into your milk to … INFORMATION XOFLUZA is contraindicated in patients with a history of hypersensitivity to These highlights do not include all the information needed to use XOFLUZA safely and effectively. See full prescribing information for XOFLUZA. XOFLUZATM (baloxavir marboxil) tablets, for oral use Initial U.S. Approval: 2018 -----INDICATIONS AND USAGE----- XOFLUZATM is a polymerase acidic (PA) …

DRUGS CONTRAINDICATED IN PREGNANCY (part 1 of 2) This chart represents information on select drugs that are contraindicated (Pregnancy category X) for women who are pregnant. This is not an inclusive list of products that carry that pregnancy category. Those drugs that are contraindicated at a certain phase of the pregnancy are listed next to the product name. For more information on specific DRUGS CONTRAINDICATED IN PREGNANCY (part 1 of 2) This chart represents information on select drugs that are contraindicated (Pregnancy category X) for women who are pregnant. This is not an inclusive list of products that carry that pregnancy category. Those drugs that are contraindicated at a certain phase of the pregnancy are listed next to the product name. For more information on specific

INFORMATION XOFLUZA is contraindicated in patients with a history of hypersensitivity to These highlights do not include all the information needed to use XOFLUZA safely and effectively. See full prescribing information for XOFLUZA. XOFLUZATM (baloxavir marboxil) tablets, for oral use Initial U.S. Approval: 2018 -----INDICATIONS AND USAGE----- XOFLUZATM is a polymerase acidic (PA) … Contraindications to Breastfeeding or Feeding Expressed Breast Milk to Infants. Physicians should make case-by-case assessments to determine whether a woman’s environmental exposure, her own medical condition, or the medical condition of the infant warrants her to interrupt, stop, or never start breastfeeding.

Drug which has been studied in a limited number of breastfeeding women without an increase in adverse effects in the infant; and/or, the evidence of a demonstrated risk which is likely to follow use of this medication in a breastfeeding woman is remote. The risk of using the drug in breastfeeding women clearly overweighs any possible benefit from breastfeeding. The drug is contraindicated in women who are breastfeeding an

Iodine has been deleted from the Summary and the Table as it is not contraindicated during breastfeeding. Few medications are contraindicated while breastfeeding. Is it safe for mothers to use prescription medications while breastfeeding? Usually. A 2013 clinical report by the American Academy of Pediatrics (AAP), “The Transfer of Drugs and Therapeutics into Human Breast Milk: An Update on Selected Topics,” indicates that most medications and immunizations are safe to use during lactation

INFORMATION XOFLUZA is contraindicated in patients with a history of hypersensitivity to These highlights do not include all the information needed to use XOFLUZA safely and effectively. See full prescribing information for XOFLUZA. XOFLUZATM (baloxavir marboxil) tablets, for oral use Initial U.S. Approval: 2018 -----INDICATIONS AND USAGE----- XOFLUZATM is a polymerase acidic (PA) … Drugs in Pregnacy and Lactation, 6th edition: Gerald G Briggs BPharm, Roger K Freeman MD, Sumner J Yaffe MD By Lippincott Williams & Wilkins Publishers

Therefore, co-administration of domperidone with certain drugs is contraindicated (see . section . 4.3 Contraindications). Caution should be exercised when domperidone is coadministered with pote- nt CYP3A4 inhibitors which have not been shown to cause QT interval prolongation or drugs which have been shown to cause QT interval prolongation (see 4.4 Special warnings and section . precautions Iodine has been deleted from the Summary and the Table as it is not contraindicated during breastfeeding.

BREASTFEEDING AND SMOKING. In the previous edition of this statement, the Committee on Drugs placed nicotine (smoking) in Table 2, “Drugs of Abuse-Contraindicated During Breastfeeding.” Even though most drugs and therapeutics are safe for breastfeeding mothers and infants, the AAP advises all physicians to obtain the most up-to-date information on drugs and lactation. Antibiotics are one of the most common medications mothers are prescribed and all pass in some degree into milk.

Therefore, co-administration of domperidone with certain drugs is contraindicated (see . section . 4.3 Contraindications). Caution should be exercised when domperidone is coadministered with pote- nt CYP3A4 inhibitors which have not been shown to cause QT interval prolongation or drugs which have been shown to cause QT interval prolongation (see 4.4 Special warnings and section . precautions Contraindicated during lactation. Some drugs contraindicated during lactation are mentioned below. If any of these drugs are considered crucial for the mother’s health, breast-feeding should be

Many mothers need to take medications during breastfeeding. Although many drugs are safe to use when you're breastfeeding, most will get into your milk to … n--NEW list of drugs contraindicated in pregnancy n --NEW list of drugs known to cause human developmental toxicity n --NEW More summaries at the beginning for pregnancy and breastfeeding

These images are a random sampling from a Bing search on the term "Medications in Lactation." Click on the image (or right click) to open the source website in a new browser window. Click on the image (or right click) to open the source website in a new browser window. Contraindications (4),and Drug Interactions (7.2)]: Loss of therapeutic effect of DELSTRIGO and possible development of resistance. Possible clinically significant adverse reactions from greater exposures of a component of